Amount of drug in given volume of plasma Solution

STEP 0: Pre-Calculation Summary
Formula Used
Concentration of Drug = Dose/Volume of Distribution
Css = D/Vdis
This formula uses 3 Variables
Variables Used
Concentration of Drug - (Measured in Mole per Cubic Meter) - Concentration of Drug is the amount of the drug in a given volume of plasma.
Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
STEP 1: Convert Input(s) to Base Unit
Dose: 8 Mole --> 8 Mole No Conversion Required
Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
Css = D/Vdis --> 8/0.009
Evaluating ... ...
Css = 888.888888888889
STEP 3: Convert Result to Output's Unit
888.888888888889 Mole per Cubic Meter -->0.888888888888889 Mole per Liter (Check conversion here)
FINAL ANSWER
0.888888888888889 0.888889 Mole per Liter <-- Concentration of Drug
(Calculation completed in 00.004 seconds)

Credits

Created by Prashant Singh
K J Somaiya College of science (K J Somaiya), Mumbai
Prashant Singh has created this Calculator and 700+ more calculators!
Verified by Prerana Bakli
University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA
Prerana Bakli has verified this Calculator and 1600+ more calculators!

25 Dose Calculators

Dose of drug administered orally
Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)
Dose of drug administered intravenous
Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous
Dose of A type drug
Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)
Dose of B type drug
Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)
Administrative dose given rate of administration and dosing interval
Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)
Previous Rate of Drug Dose given Revised Dose
Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)
Dosing interval given rate of administration
Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration
Revised Dose
Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma
Loading Dose
Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose
Maintenance Dose
Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/ Bioavailability Of drug dose
Dose given volume of distribution and area under curve
Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve
Administrative Dose given Drug Purity
Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)
Effective dose given drug purity
Go Effective Dose = Drug Purity*Bioavailability*Administered Dose
Adult Dose of Drug by Clark's Equation in Micrograms
Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)
Clark's Equation of Dosage in Microgram
Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)
Dosing interval given average plasma concentration
Go Dosing Interval = Area Under Curve/Average Plasma Concentration
Weight of Patient in Kilograms by Clark's equation
Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68
Adult Dose of Drug by Clark's Equation
Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)
Weight of Patient by Clark's equation
Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150
Clark's Equation of Dosage
Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)
Amount of drug administered given apparent volume
Go Dose = Volume of Distribution*Concentration of Drug
Amount of drug in given volume of plasma
Go Concentration of Drug = Dose/Volume of Distribution
Administrative dose given effective dose and bioavailability
Go Administered Dose = Effective Dose/Bioavailability
Effective dose given bioavailability and administrative dose
Go Effective Dose = Bioavailability*Administered Dose
Amount of drug administered given area under curve
Go Dose = Volume of Plasma Cleared*Area Under Curve

Amount of drug in given volume of plasma Formula

Concentration of Drug = Dose/Volume of Distribution
Css = D/Vdis

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Amount of drug in given volume of plasma?

Amount of drug in given volume of plasma calculator uses Concentration of Drug = Dose/Volume of Distribution to calculate the Concentration of Drug, Amount of drug in given volume of plasma formula is defined as ratio of amount of drug administered to apparent volume of drug. Concentration of Drug is denoted by Css symbol.

How to calculate Amount of drug in given volume of plasma using this online calculator? To use this online calculator for Amount of drug in given volume of plasma, enter Dose (D) & Volume of Distribution (Vdis) and hit the calculate button. Here is how the Amount of drug in given volume of plasma calculation can be explained with given input values -> 0.000889 = 8/0.009.

FAQ

What is Amount of drug in given volume of plasma?
Amount of drug in given volume of plasma formula is defined as ratio of amount of drug administered to apparent volume of drug and is represented as Css = D/Vdis or Concentration of Drug = Dose/Volume of Distribution. The Dose is the amount of drug administered & The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
How to calculate Amount of drug in given volume of plasma?
Amount of drug in given volume of plasma formula is defined as ratio of amount of drug administered to apparent volume of drug is calculated using Concentration of Drug = Dose/Volume of Distribution. To calculate Amount of drug in given volume of plasma, you need Dose (D) & Volume of Distribution (Vdis). With our tool, you need to enter the respective value for Dose & Volume of Distribution and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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