Average Concentration of Plasma at Steady State Solution

STEP 0: Pre-Calculation Summary
Formula Used
Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
c̅pss = D/(CL*Τ)
This formula uses 4 Variables
Variables Used
Average Concentration of Plasma at Steady State - (Measured in Mole per Cubic Meter) - Average Concentration of Plasma at Steady State is the amount of a drug in a given volume of blood plasma of the sample.
Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.
Dosing Interval - (Measured in Second) - The Dosing Interval is the time between drug dose administrations.
STEP 1: Convert Input(s) to Base Unit
Dose: 8 Mole --> 8 Mole No Conversion Required
Volume of Plasma Cleared: 0.48 Liter per Second --> 0.00048 Cubic Meter per Second (Check conversion here)
Dosing Interval: 44 Second --> 44 Second No Conversion Required
STEP 2: Evaluate Formula
Substituting Input Values in Formula
c̅pss = D/(CL*Τ) --> 8/(0.00048*44)
Evaluating ... ...
c̅pss = 378.787878787879
STEP 3: Convert Result to Output's Unit
378.787878787879 Mole per Cubic Meter -->0.378787878787879 Mole per Liter (Check conversion here)
FINAL ANSWER
0.378787878787879 0.378788 Mole per Liter <-- Average Concentration of Plasma at Steady State
(Calculation completed in 00.004 seconds)

Credits

Created by Soupayan banerjee
National University of Judicial Science (NUJS), Kolkata
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University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA
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11 Plasma Calculators

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Apparent Tissue Volume given Plasma Volume and Apparent Volume
Go Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
Plasma Volume of Drug given Apparent Volume
Go Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
Renal Clearance using Rate of Reabsorption
Go Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration
Average Plasma Concentration given Peak through Fluctuation
Go Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation
Lowest Plasma Concentration Given Peak through Fluctuation
Go Lowest Plasma Concentration = Peak Plasma Concentration-(Average Plasma Concentration*Peak Through Fluctuation)
Peak Plasma Concentration Given Peak through Fluctuation
Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration
Peak through Fluctuation
Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration
Average Concentration of Plasma at Steady State
Go Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
Plasma Concentration of Constant Rate Infusion at Steady State
Go Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance
Initial Concentration for Intravenous Bolus
Go Initial Plasma Concentration = Dose/Volume of Distribution

Average Concentration of Plasma at Steady State Formula

Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
c̅pss = D/(CL*Τ)

What is Pharmacokinetics?

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.

How to Calculate Average Concentration of Plasma at Steady State?

Average Concentration of Plasma at Steady State calculator uses Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval) to calculate the Average Concentration of Plasma at Steady State, The Average Concentration of Plasma at Steady State formula is defined as the concentration of an agent in the plasma which is derived from full blood. Plasma concentrations are used to define major PK and PK/PD parameters. Average Concentration of Plasma at Steady State is denoted by c̅pss symbol.

How to calculate Average Concentration of Plasma at Steady State using this online calculator? To use this online calculator for Average Concentration of Plasma at Steady State, enter Dose (D), Volume of Plasma Cleared (CL) & Dosing Interval (Τ) and hit the calculate button. Here is how the Average Concentration of Plasma at Steady State calculation can be explained with given input values -> 0.000379 = 8/(0.00048*44).

FAQ

What is Average Concentration of Plasma at Steady State?
The Average Concentration of Plasma at Steady State formula is defined as the concentration of an agent in the plasma which is derived from full blood. Plasma concentrations are used to define major PK and PK/PD parameters and is represented as c̅pss = D/(CL*Τ) or Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval). The Dose is the amount of drug administered, The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time & The Dosing Interval is the time between drug dose administrations.
How to calculate Average Concentration of Plasma at Steady State?
The Average Concentration of Plasma at Steady State formula is defined as the concentration of an agent in the plasma which is derived from full blood. Plasma concentrations are used to define major PK and PK/PD parameters is calculated using Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval). To calculate Average Concentration of Plasma at Steady State, you need Dose (D), Volume of Plasma Cleared (CL) & Dosing Interval (Τ). With our tool, you need to enter the respective value for Dose, Volume of Plasma Cleared & Dosing Interval and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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