Dose of drug administered intravenous Solution

STEP 0: Pre-Calculation Summary
Formula Used
Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous
Div = (f*AUCiv*Dpo)/AUCpo
This formula uses 5 Variables
Variables Used
Dose Intravenous - (Measured in Mole) - The Dose Intravenous is the amount of drug administered intravenously.
Bioavailability of Drug - The Bioavailability of Drug is defined as the systemically available fraction of a drug.
Area under Curve Intravenous - (Measured in Mole Second per Cubic Meter) - Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous.
Dose Non-Intravenous - (Measured in Mole) - The Dose Non-Intravenous is the amount of drug administered orally.
Area under Curve Non-Intravenous - (Measured in Mole Second per Cubic Meter) - The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally.
STEP 1: Convert Input(s) to Base Unit
Bioavailability of Drug: 9.5 --> No Conversion Required
Area under Curve Intravenous: 11 Mole Second per Liter --> 11000 Mole Second per Cubic Meter (Check conversion here)
Dose Non-Intravenous: 4 Mole --> 4 Mole No Conversion Required
Area under Curve Non-Intravenous: 6 Mole Second per Liter --> 6000 Mole Second per Cubic Meter (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
Div = (f*AUCiv*Dpo)/AUCpo --> (9.5*11000*4)/6000
Evaluating ... ...
Div = 69.6666666666667
STEP 3: Convert Result to Output's Unit
69.6666666666667 Mole --> No Conversion Required
FINAL ANSWER
69.6666666666667 69.66667 Mole <-- Dose Intravenous
(Calculation completed in 00.020 seconds)

Credits

Created by Prashant Singh
K J Somaiya College of science (K J Somaiya), Mumbai
Prashant Singh has created this Calculator and 700+ more calculators!
Verified by Prerana Bakli
University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA
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25 Dose Calculators

Dose of drug administered orally
Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)
Dose of drug administered intravenous
Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous
Dose of A type drug
Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)
Dose of B type drug
Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)
Administrative dose given rate of administration and dosing interval
Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)
Previous Rate of Drug Dose given Revised Dose
Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)
Dosing interval given rate of administration
Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration
Revised Dose
Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma
Loading Dose
Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose
Maintenance Dose
Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/ Bioavailability Of drug dose
Dose given volume of distribution and area under curve
Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve
Administrative Dose given Drug Purity
Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)
Effective dose given drug purity
Go Effective Dose = Drug Purity*Bioavailability*Administered Dose
Adult Dose of Drug by Clark's Equation in Micrograms
Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)
Clark's Equation of Dosage in Microgram
Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)
Dosing interval given average plasma concentration
Go Dosing Interval = Area Under Curve/Average Plasma Concentration
Weight of Patient in Kilograms by Clark's equation
Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68
Adult Dose of Drug by Clark's Equation
Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)
Weight of Patient by Clark's equation
Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150
Clark's Equation of Dosage
Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)
Amount of drug administered given apparent volume
Go Dose = Volume of Distribution*Concentration of Drug
Amount of drug in given volume of plasma
Go Concentration of Drug = Dose/Volume of Distribution
Administrative dose given effective dose and bioavailability
Go Administered Dose = Effective Dose/Bioavailability
Effective dose given bioavailability and administrative dose
Go Effective Dose = Bioavailability*Administered Dose
Amount of drug administered given area under curve
Go Dose = Volume of Plasma Cleared*Area Under Curve

Dose of drug administered intravenous Formula

Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous
Div = (f*AUCiv*Dpo)/AUCpo

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Dose of drug administered intravenous?

Dose of drug administered intravenous calculator uses Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous to calculate the Dose Intravenous, The Dose of drug administered intravenous formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration. Dose Intravenous is denoted by Div symbol.

How to calculate Dose of drug administered intravenous using this online calculator? To use this online calculator for Dose of drug administered intravenous, enter Bioavailability of Drug (f), Area under Curve Intravenous (AUCiv), Dose Non-Intravenous (Dpo) & Area under Curve Non-Intravenous (AUCpo) and hit the calculate button. Here is how the Dose of drug administered intravenous calculation can be explained with given input values -> 69.66667 = (9.5*11000*4)/6000.

FAQ

What is Dose of drug administered intravenous?
The Dose of drug administered intravenous formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration and is represented as Div = (f*AUCiv*Dpo)/AUCpo or Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous. The Bioavailability of Drug is defined as the systemically available fraction of a drug, Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous, The Dose Non-Intravenous is the amount of drug administered orally & The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally.
How to calculate Dose of drug administered intravenous?
The Dose of drug administered intravenous formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration is calculated using Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous. To calculate Dose of drug administered intravenous, you need Bioavailability of Drug (f), Area under Curve Intravenous (AUCiv), Dose Non-Intravenous (Dpo) & Area under Curve Non-Intravenous (AUCpo). With our tool, you need to enter the respective value for Bioavailability of Drug, Area under Curve Intravenous, Dose Non-Intravenous & Area under Curve Non-Intravenous and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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