Inhibitor Concentration given Modifying Factor of Enzyme Solution

STEP 0: Pre-Calculation Summary
Formula Used
Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant
I = (α-1)*Ki
This formula uses 3 Variables
Variables Used
Inhibitor Concentration - (Measured in Mole per Cubic Meter) - The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.
Enzyme Modifying Factor - The Enzyme Modifying Factor is defined by the inhibitor concentration and the dissociation constants of enzyme.
Enzyme Inhibitor Dissociation Constant - (Measured in Mole per Cubic Meter) - The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.
STEP 1: Convert Input(s) to Base Unit
Enzyme Modifying Factor: 5 --> No Conversion Required
Enzyme Inhibitor Dissociation Constant: 19 Mole per Liter --> 19000 Mole per Cubic Meter (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
I = (α-1)*Ki --> (5-1)*19000
Evaluating ... ...
I = 76000
STEP 3: Convert Result to Output's Unit
76000 Mole per Cubic Meter -->76 Mole per Liter (Check conversion here)
FINAL ANSWER
76 Mole per Liter <-- Inhibitor Concentration
(Calculation completed in 00.004 seconds)

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Substrate Concentration in Enzymatic Reaction Mechanism
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Enzyme Catalyst Concentration given Forward, Reverse, and Catalytic Rate Constants
Go Catalyst Concentration = ((Reverse Rate Constant+Catalytic Rate Constant)*Enzyme Substrate Complex Concentration)/(Forward Rate Constant*Substrate Concentration)
Substrate Concentration given Forward, Reverse, and Catalytic Rate Constants
Go Substrate Concentration = ((Reverse Rate Constant+Catalytic Rate Constant)*Enzyme Substrate Complex Concentration)/(Forward Rate Constant*Catalyst Concentration)
Initial Enzyme Concentration given Catalytic Rate Constant and Dissociation Rate Constants
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Go Substrate Concentration = (Dissociation Rate Constant*Initial Reaction Rate)/((Catalytic Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate)
Substrate Concentration given Catalytic Rate Constant and Initial Enzyme Concentration
Go Concentration of Substrate = (Michaelis Constant*Initial Reaction Rate)/((Catalytic Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate)
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Inhibitor Concentration given Apparent Initial Enzyme Concentration
Go Inhibitor Concentration for CI = ((Initial Enzyme Concentration/Apparent Initial Enzyme Concentration)-1)*Enzyme Inhibitor Dissociation Constant
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Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex
Go Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant
Inhibitor Concentration given Enzyme Substrate Modifying Factor
Go Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant
Inhibitor Concentration given Modifying Factor of Enzyme
Go Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant
Enzyme Substrate Complex Concentration given Rate Constant and Initial Rate
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Initial Enzyme Concentration given Rate Constant and Maximum Rate
Go Initial Enzyme Concentration = Maximum Rate/Final Rate Constant

Inhibitor Concentration given Modifying Factor of Enzyme Formula

Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant
I = (α-1)*Ki

What is competitive Inhibition?

In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time, as shown in the figure on the right. This usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate and inhibitor compete for access to the enzyme's active site. This type of inhibition can be overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. However, the apparent Km will increase as it takes a higher concentration of the substrate to reach the Km point, or half the Vmax. Competitive inhibitors are often similar in structure to the real substrate.

How to Calculate Inhibitor Concentration given Modifying Factor of Enzyme?

Inhibitor Concentration given Modifying Factor of Enzyme calculator uses Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant to calculate the Inhibitor Concentration, The Inhibitor concentration given modifying factor of enzyme formula is defined as the relation with modifying factor of enzyme and with the enzyme inhibitor dissociation constant. Inhibitor Concentration is denoted by I symbol.

How to calculate Inhibitor Concentration given Modifying Factor of Enzyme using this online calculator? To use this online calculator for Inhibitor Concentration given Modifying Factor of Enzyme, enter Enzyme Modifying Factor (α) & Enzyme Inhibitor Dissociation Constant (Ki) and hit the calculate button. Here is how the Inhibitor Concentration given Modifying Factor of Enzyme calculation can be explained with given input values -> 0.076 = (5-1)*19000.

FAQ

What is Inhibitor Concentration given Modifying Factor of Enzyme?
The Inhibitor concentration given modifying factor of enzyme formula is defined as the relation with modifying factor of enzyme and with the enzyme inhibitor dissociation constant and is represented as I = (α-1)*Ki or Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant. The Enzyme Modifying Factor is defined by the inhibitor concentration and the dissociation constants of enzyme & The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.
How to calculate Inhibitor Concentration given Modifying Factor of Enzyme?
The Inhibitor concentration given modifying factor of enzyme formula is defined as the relation with modifying factor of enzyme and with the enzyme inhibitor dissociation constant is calculated using Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant. To calculate Inhibitor Concentration given Modifying Factor of Enzyme, you need Enzyme Modifying Factor (α) & Enzyme Inhibitor Dissociation Constant (Ki). With our tool, you need to enter the respective value for Enzyme Modifying Factor & Enzyme Inhibitor Dissociation Constant and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
How many ways are there to calculate Inhibitor Concentration?
In this formula, Inhibitor Concentration uses Enzyme Modifying Factor & Enzyme Inhibitor Dissociation Constant. We can use 2 other way(s) to calculate the same, which is/are as follows -
  • Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant
  • Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant
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