Renal Clearance of Drug Solution

STEP 0: Pre-Calculation Summary
Formula Used
Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve
CLr = Au/AUC
This formula uses 3 Variables
Variables Used
Renal Clearance - (Measured in Cubic Meter per Second) - Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time.
Drug Amount Excreted Unchanged in Urine - (Measured in Kilogram per Cubic Meter) - Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine.
Area Under Curve - (Measured in Mole Second per Cubic Meter) - Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.
STEP 1: Convert Input(s) to Base Unit
Drug Amount Excreted Unchanged in Urine: 8.2 Microgram per Liter --> 8.2E-06 Kilogram per Cubic Meter (Check conversion here)
Area Under Curve: 1.32 Mole Second per Liter --> 1320 Mole Second per Cubic Meter (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
CLr = Au/AUC --> 8.2E-06/1320
Evaluating ... ...
CLr = 6.21212121212121E-09
STEP 3: Convert Result to Output's Unit
6.21212121212121E-09 Cubic Meter per Second -->0.372727272727273 Milliliter per Minute (Check conversion here)
FINAL ANSWER
0.372727272727273 0.372727 Milliliter per Minute <-- Renal Clearance
(Calculation completed in 00.004 seconds)

Credits

Created by Soupayan banerjee
National University of Judicial Science (NUJS), Kolkata
Soupayan banerjee has created this Calculator and 200+ more calculators!
Verified by Prerana Bakli
University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA
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25 Drug Content Calculators

Saponification value
Go Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken
Fraction of Drug Unbound in Tissue given Apparent Tissue Volume
Go Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)
Secretion Rate of Drug
Go Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)
Reabsorption Rate of Drug
Go Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)
Filtration Rate of Drug
Go Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)
Relative Bioavailability of Drug
Go Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)
Acid Value of KOH
Go Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken
Drug Purity given Rate of Administration and Dosing Interval
Go Drug Purity = (Drug Rate*Dosing Interval)/(Administered Dose*Bioavailability)
Rate of Administration of Drug given Dosing Interval
Go Drug Rate = (Administered Dose*Bioavailability*Drug Purity)/Dosing Interval
Drug Purity given Administrative Dose and Effective Dose
Go Drug Purity = Effective Dose/(Administered Dose*Bioavailability)
Drug Loading Efficiency
Go Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100
Encapsulation Efficiency
Go Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100
Renal Clearance of Drug
Go Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve
Concentration of Drug given Rate of Infusion of Drug
Go Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared
Rate of Infusion of Drug
Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug
Median Lethal Dose using Therapeutic Index
Go Median Lethal Dose = (Median Effective Dose*Therapeutic Index)
Margin of Safety of Drugs
Go Margin of Safety = Toxic Dose Response/Effective Dose Response
Effective Dose using Therapeutic Index
Go Median Effective Dose = Median Lethal Dose/Therapeutic Index
Therapeutic Index
Go Therapeutic Index = Median Lethal Dose/Median Effective Dose
Absorption Half-Life of Drug
Go Absorption Half Life = ln(2)/Absorption Rate Constant
Drug Rate Entering Body
Go Absorption Rate Constant = ln(2)/Absorption Half Life
Concentration of Drug using Volume of Distribution
Go Concentration of Drug = Dose/Volume of Distribution
Apparent Volume of Drug Distribution
Go Volume of Distribution = Dose/Concentration of Drug
Tablet Dosage
Go Number of tablet = Desired dosage/Stock strength
Easter Value
Go Easter Value = Saponification Value-Acid Value

Renal Clearance of Drug Formula

Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve
CLr = Au/AUC

What is Pharmacokinetics ?

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.

How to Calculate Renal Clearance of Drug?

Renal Clearance of Drug calculator uses Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve to calculate the Renal Clearance, The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute. Renal Clearance is denoted by CLr symbol.

How to calculate Renal Clearance of Drug using this online calculator? To use this online calculator for Renal Clearance of Drug, enter Drug Amount Excreted Unchanged in Urine (Au) & Area Under Curve (AUC) and hit the calculate button. Here is how the Renal Clearance of Drug calculation can be explained with given input values -> 2.2E+7 = 8.2E-06/1320.

FAQ

What is Renal Clearance of Drug?
The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute and is represented as CLr = Au/AUC or Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve. Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine & Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.
How to calculate Renal Clearance of Drug?
The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute is calculated using Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve. To calculate Renal Clearance of Drug, you need Drug Amount Excreted Unchanged in Urine (Au) & Area Under Curve (AUC). With our tool, you need to enter the respective value for Drug Amount Excreted Unchanged in Urine & Area Under Curve and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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