Renal Clearance using Rate of Reabsorption Solution

STEP 0: Pre-Calculation Summary
Formula Used
Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration
CLr = Frate+(Srate-Rrate)/Cp
This formula uses 5 Variables
Variables Used
Renal Clearance - (Measured in Cubic Meter per Second) - Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time.
Filtration Rate - (Measured in Cubic meter per second) - Filtration Rate is the estimates of how much blood passes through the glomeruli each minute.
Secretion Rate of Drug - (Measured in Cubic meter per second) - Secretion Rate of Drug is the measure of the removal of drugs from the body, either as a metabolite or unchanged drug.
Reabsorption Rate of Drug - (Measured in Cubic meter per second) - Reabsorption Rate of Drug is the measure of movement of drug and solutes from the tubule back into the plasma.
Plasma Concentration - (Measured in Mole per Cubic Meter) - Plasma Concentration is the concentration of the drug after administration and before the next dose is administered.
STEP 1: Convert Input(s) to Base Unit
Filtration Rate: 14 Milliliter per Minute --> 2.33333333333333E-07 Cubic meter per second (Check conversion here)
Secretion Rate of Drug: 10.4 Milliliter per Minute --> 1.73333333333333E-07 Cubic meter per second (Check conversion here)
Reabsorption Rate of Drug: 14.5 Milliliter per Minute --> 2.41666666666667E-07 Cubic meter per second (Check conversion here)
Plasma Concentration: 17 Mole per Liter --> 17000 Mole per Cubic Meter (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
CLr = Frate+(Srate-Rrate)/Cp --> 2.33333333333333E-07+(1.73333333333333E-07-2.41666666666667E-07)/17000
Evaluating ... ...
CLr = 2.3332931372549E-07
STEP 3: Convert Result to Output's Unit
2.3332931372549E-07 Cubic Meter per Second -->13.9997588235294 Milliliter per Minute (Check conversion here)
FINAL ANSWER
13.9997588235294 13.99976 Milliliter per Minute <-- Renal Clearance
(Calculation completed in 00.004 seconds)

Credits

Created by Soupayan banerjee
National University of Judicial Science (NUJS), Kolkata
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11 Plasma Calculators

Fractional Excretion of Sodium
Go Fractional Excretion of Sodium = (Urine Sodium Concentration*Creatinine Concentration in Plasma)/(Sodium Concentration in Plasma*Creatinine Concentration in Urine)*100
Apparent Tissue Volume given Plasma Volume and Apparent Volume
Go Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
Plasma Volume of Drug given Apparent Volume
Go Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
Renal Clearance using Rate of Reabsorption
Go Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration
Average Plasma Concentration given Peak through Fluctuation
Go Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation
Lowest Plasma Concentration Given Peak through Fluctuation
Go Lowest Plasma Concentration = Peak Plasma Concentration-(Average Plasma Concentration*Peak Through Fluctuation)
Peak Plasma Concentration Given Peak through Fluctuation
Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration
Peak through Fluctuation
Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration
Average Concentration of Plasma at Steady State
Go Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
Plasma Concentration of Constant Rate Infusion at Steady State
Go Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance
Initial Concentration for Intravenous Bolus
Go Initial Plasma Concentration = Dose/Volume of Distribution

Renal Clearance using Rate of Reabsorption Formula

Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration
CLr = Frate+(Srate-Rrate)/Cp

What is Pharmacokinetics ?

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.

How to Calculate Renal Clearance using Rate of Reabsorption?

Renal Clearance using Rate of Reabsorption calculator uses Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration to calculate the Renal Clearance, The Renal Clearance using Rate of reabsorption formula is defined as measurement of the volume of plasma that is removed of a specific substance over a period of time without a negligible reabsorption of drug. Renal Clearance is denoted by CLr symbol.

How to calculate Renal Clearance using Rate of Reabsorption using this online calculator? To use this online calculator for Renal Clearance using Rate of Reabsorption, enter Filtration Rate (Frate), Secretion Rate of Drug (Srate), Reabsorption Rate of Drug (Rrate) & Plasma Concentration (Cp) and hit the calculate button. Here is how the Renal Clearance using Rate of Reabsorption calculation can be explained with given input values -> 8.4E+8 = 2.33333333333333E-07+(1.73333333333333E-07-2.41666666666667E-07)/17000.

FAQ

What is Renal Clearance using Rate of Reabsorption?
The Renal Clearance using Rate of reabsorption formula is defined as measurement of the volume of plasma that is removed of a specific substance over a period of time without a negligible reabsorption of drug and is represented as CLr = Frate+(Srate-Rrate)/Cp or Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration. Filtration Rate is the estimates of how much blood passes through the glomeruli each minute, Secretion Rate of Drug is the measure of the removal of drugs from the body, either as a metabolite or unchanged drug, Reabsorption Rate of Drug is the measure of movement of drug and solutes from the tubule back into the plasma & Plasma Concentration is the concentration of the drug after administration and before the next dose is administered.
How to calculate Renal Clearance using Rate of Reabsorption?
The Renal Clearance using Rate of reabsorption formula is defined as measurement of the volume of plasma that is removed of a specific substance over a period of time without a negligible reabsorption of drug is calculated using Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration. To calculate Renal Clearance using Rate of Reabsorption, you need Filtration Rate (Frate), Secretion Rate of Drug (Srate), Reabsorption Rate of Drug (Rrate) & Plasma Concentration (Cp). With our tool, you need to enter the respective value for Filtration Rate, Secretion Rate of Drug, Reabsorption Rate of Drug & Plasma Concentration and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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